You should pull up and remove weeds by hand as and when they appear. If it is a regular problem, you might need to reseal the paving. In extreme cases, the sub layer itself may need to be re-laid. You can use weed killer, however some paving can be discoloured by stronger weed killers.
Mindrum
Mindrum is a town in Northumberland, England, in the district of Berwick-upon-Tweed. Currently little bit more than a postal address, it develops the centre of a variety of ranches. Mindrum is situated on the North West Foothills of the Cheviot Hills on the Bowmont Water, among the Tributaries of the River Tweed. Whilst the term Mountain might be hopeful, the town is flanked by a clear ridge ranging from Camp Hill to the Mindrum Mill Crag on its North West Flank.